If you ever feared the possibility of you or your loved ones developing Alzheimer’s, here a good news for you.
Researchers claim that a breakthrough in Alzheimer’s treatment that holds the promise that it could reverse or even prevent the disease.
According to scientists, this treatment has the potential to revolutionize Alzheimer’s treatment.
This Researchers from UK and Germany developed an antibody-based treatment and a protein-based vaccine that diminished Alzheimer’s symptoms in mice. Of course, the next crucial step will be to run human clinical trials.
Alzheimer’s disease is a neurologic disorder that causes the brain to shrink and brain cells to die.
It is the most common cause of dementia causing a continuous decline in thinking, behavioral and social skills that affect a person’s ability to function independently.
Approximately 5.8 million people in the United States age 65 and older live with Alzheimer’s disease. Of those, 80% are 75 years old and older. Approximately 50 million people worldwide are suffering from dementia, between 60% and 70% are estimated to have Alzheimer’s disease.
The early symptoms include forgetting recent events or conversations. As the disease progresses, a person with Alzheimer’s disease will develop severe memory impairment and lose the ability to carry out everyday tasks.
Sadly, there are currently no effective treatments to prevent, slow down, or reverse the disease.
But this treatment brings hope
How does this treatment work?
One of the signs of Alzheimer’s disease is the build-up of abnormal structures called ‘amyloid plaques’ in the brain from a protein called Amyloid-beta protein.
The amyloid beta-protein naturally exists in many different forms in the brain of Alzheimer’s.
It can join together, eventually forming plaques that collect between nerve cells, But the same protein also comes in abnormal structure or truncated soluble forms, which some scientists now believe is the major factor in the development and progression of the disease. Learn more
Professor Thomas Bayer, from the University Medical Center Göttingen, who is co-author of the study said:
“We identified an antibody in mice that would neutralize the truncated forms of soluble amyloid-beta but would not bind either to normal forms of the protein or to the plaques.”
The team adapted the antibody, called TAP01, and engineered a vaccine based on the study.
In tests, both the antibody and the engineered vaccine repaired the brain’s neuron function and increased glucose metabolism in the brain, bringing back the memories of the mice.
Professor Mark Carr, of Leicester University, said:
“If these results were replicated in human trials, then it could be transformative.
“It opens up the possibility to not only treat Alzheimer’s but also to potentially vaccinate against the disease before the symptoms appear.”
This brings hope to many people, even if the studies and treatments are in their early stage we can hope for further progress and improvements
The research is published in a journal called Molecular Psychiatry.
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